Systems and methods to affect anatomical structures

A method for affecting an anatomical structure, comprising:

• adapting a nanofiber mesh to an anatomical structure of a subject so that the nanofiber mesh substantially conforms to the anatomical structure, wherein the at least a portion of the nanofiber mesh defines a fillable space;
• and
• flowing a carrier substance into the fillable space, wherein the carrier substance comprises an active agent, and wherein at least a portion of the carrier substance is disposed within the fillable space.

A kit for affecting an anatomical structure, comprising:

• a membrane configured to substantially conform to an anatomical structure, wherein at least a portion of the membrane can define a fillable space;
• and
• a flowable hydrogel system comprising at least one active agent.