Methods and apparatuses related to blood analyte measurement system

An apparatus for measuring an analyte in blood taken from a patient, comprising:

• a. A patient interface device, capable of interfacing with the circulatory system of a patient;
• b. An analyte sensor having first and second ports, with the first port in fluid communication with the patient interface device;
• c. A flow generation and reservoir system having first and second ports, with the first port in fluid communication with second port of the analyte sensor;
• d. A first fluid source, mounted such that it can be placed in fluid communication with the second port of the flow generation and reservoir system, wherein the first fluid source provides a first fluid having a first predetermined analyte concentration;
• and
• e. A second fluid source, mounted such that it can be placed in fluid communication with the second port of the analyte sensor, wherein the second fluid source provides a second fluid having a second predetermined analyte concentration, where the second predetermined analyte concentration is different than the first predetermined analyte concentration.

An apparatus for the measurement of an analyte, comprising:

• a. A patient interface device capable of interfacing with the circulatory system of a patient;
• b. An analyte sensor having first and second ports, with the first port in fluid communication with the patient interface device;
• c. A flow generation device having first and second ports, with the first port in fluid communication with second port of the analyte sensor;
• d. A waste channel in fluid communication with the second port of the flow generation device through a first flow control device that allows fluid flow from the flow generation device to the waste channel but substantially prevents fluid from the waste channel to the flow generation device;
• e. A first fluid source, mounted such that it can be placed in fluid communication with the second port of the flow generation device through a second flow control device that allows fluid flow from the first fluid source to the flow generation device but substantially prevents fluid from the flow generation device to the first fluid source, wherein the first fluid source provides a first fluid having a first predetermined analyte concentration.