Ethoid-Containing Compounds, Methods for Preparing Ethoid-Containing Compounds, and Methods of Use

A compound comprising a polyethoid moiety having a formula

• wherein:
• m is an integer ≧0;
• each a is an independently selected integer=1 or =2;
• R1, each R2 and R4 are each (i) an independently selected side chain moiety selected from the group consisting of H, C1-C10 alkyl and substituted C1-C10 alkyl, which in each case can optionally form one or more ring structures, or (ii) an independently selected side chain moiety having a structure of an amino acid side chain;
• R3 is (a) a side chain moiety selected from the group consisting of RC, RD, RE, RF, RH, RI, RK, RL, RM, RN, RP, RQ, RR, RT, RU, RV, RW and RY, each as delineated in Table I.A, (b) a side chain moiety selected from and having a structure of a non-natural amino acid side chain as delineated in Table I.B.1 or in Table I.C.1 or (c) a protected derivative of the foregoing side chain moieties;
• R1′, each R2′, R3′ and R4′ are each independently selected from the group consisting of H, C1-C3 alkyl and substituted C1-C3 alkyl;
• each R10 is independently selected from the group consisting of H, C1-C3 alkyl and substituted C1-C3 alkyl;
• each V is independently selected from the group consisting of —C(O)NH— and -ψ[ ]-;
• and
• Y and Z are each independently selected from the group consisting of H, hydrocarbyl and substituted hydrocarbyl.