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AssigneeMatrix Laboratories Limited
InventorsChava Satyanarayana, Gorantla Seeta Ramanjaneyulu, Indukuri Venkata Sunil Kumar
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The present invention relates to a process for the preparation of Montelukast or a salt thereof comprises, i) condensing Methyl-2-[3-[3-(2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-chloro propyljbenzoate obtained above with 1-(mercaptomethyl)cyclopropane acetic acid in presence of alkali carbonates such as Cesium Carbonate, followed by salification with organic amine ii) neutralizing the organic amine salt as obtained above with organic/inorganic acid followed by reaction with methylmagnesium chloride in the presence of Cerium Chloride followed by treatment with organic base yields montelukast amine salt iii) converting the montelukast amine salt to Montelukast Free acid iv) saltification of Montelukast free acid with Sodium hydroxide affords Montelukast Sodium.
A process for the preparation of Montelukast or a salt thereof, comprising steps:
The process as claimed in claim 9, wherein sodium hydroxide is ethanolic sodium hydroxide
A process for the preparation of Montelukast or a salt thereof, comprising steps:
The process as claimed in claim 12, wherein the alkali carbonate is Cesium Carbonate
2-[1-[1(R)-[3-[2-(7-Chloroquinolin-2yl)ethenyl)phenyl]-3-[2-(methoxycarbonyl)phenyl]propyl sulfanyl methyl]cyclopropyl]acetic acid α-methyl benzyl amine salt characterized by FTIR spectrum as shown in FIG. 1
2-[1-[1(R)-[3-[2-(7-Chloroquinolin-2yl)ethenyl)phenyl]-3-[2-(methoxycarbonyl)phenyl]propyl sulfanyl methyl]cyclopropyl]acetic acid (S)-cyclohexyl ethyl amine salt characterized by FTIR spectrum as shown in FIG. 2.
2-[1-[1(R)-[3-[2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methyl ethyl)phenyl]propyl sulfanyl methyl]cyclopropyl acetic acid (S)-cyclohexyl ethyl amine salt characterized by FTIR spectrum as shown in FIG. 3
Dependencies are inferred from the claim text.