Loading patent…
AssigneeOoo 'Farmving'
InventorsRobert G. Glushkov, Sergei D. Juzhakov, Olga S. Fominova, Nelli M. Sazonova, Elena M. Dolginova, Vadim A. Shorr, Mikhail V. Borovkov, Valentina V. Asnina
Estimating the term…
The invention relates to a range of original xanthine derivatives substituted in 1- and 7-positions with benzhydryl-4-piperazinyl-1-alkane fragments. A method for obtaining 3-methyl-7-[4-(benzhydryl-4-piperazinyl-1)butyl]xanthine and the salts thereof with organic and inorganic acids by alkylating the 7-potassium salt of 3-methylxanthine by 1,4-dibromobutane, by subsequently interacting the thus formed 7-(4-bromobutyl)-3-methylxanthine with 1-benzhydrylpiperazinyl and by neutralising the thus obtained radical 7-/4-(4-benzhydrylpiperazinyl-1) butyl/-3-methylxanthine by an organic or inorganic acid is also disclosed.
Derivatives of 1- and 7-[{acute over (ω)}-(benzhydryl-4-piperazinyl-1)alkyl]-3-alkylxanthines of general formulae I and II:
A method of deriving 3-methyl-7-[4-(benzhydryl-4-piperazinyl-1)butyl]xanthine and its salts with organic and inorganic acids, of general formula XI:
Dependencies are inferred from the claim text.