Antibody modulating the differentiation and function of dendritic cells via binding intercellular adhesion molecule-1 and use thereof
AssigneeSnu R&Db Foundation
InventorsSEONG-HOE PARK, KYEONG-CHEON JUNG, YOUNGMEE BAE, SEONG-PYO PARK, YOON-KYUNG JEON
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Abstract
The present invention relates to an antibody binding to human intercellular adhesion molecule-1 (ICAM-1) where the antibody is able to modulate the differentiation status of dendritic cells and prolong the graft survival. In addition, the present invention provides a pharmaceutical composition comprising the antibody, and method of using them for the treatment of disease.
Claims19
An antibody that competes with an antibody produced by a hybridoma deposited as an accession number of KCLRF-BP-00198 for binding to domain 1 of human intercellular adhesion molecules-1 (ICAM-1).
An antibody that binds to domain 1 of human ICAM-1 without inhibiting the binding of human ICAM-1 to human leukocyte function antigen-1 (LFA-1).
An antibody binding to human ICAM-1 comprising a heavy chain and a light chain, the heavy chain comprising three CDRs from the heavy chain of an antibody produced by a hybridoma deposited as an accession number of KCLRF-BP-00198 and the light chain comprising three CDRs from the light chain of an antibody produced by a hybridoma deposited as an accession number of KCLRF-BP-00198.
A pharmaceutical composition comprising an antibody binding to human ICAM-1 comprising a heavy chain and a light chain, the heavy chain comprising three CDRs from the heavy chain of an antibody produced by a hybridoma deposited as an accession number of KCLRF-BP-00198 and the light chain comprising three CDRs from the light chain of an antibody produced by a hybridoma deposited as an accession number of KCLRF-BP-00198.
A hybridoma producing an antibody that wherein the antibody binds to domain 1 of human intercellular adhesion molecules-1 (ICAM-1), which is deposited as an accession number of KCLRF-BP-00198.
Dependencies are inferred from the claim text.