Conjugates of membrane translocating agents and pharmaceutically active agents
AssigneeMerrion Research III Limited
InventorsDaniel O'Mahony, Imelda Lambkin, Clemencia Pinilla, Richard Houghten
Life of this patent
Estimating the term…
Abstract
Membrane translocation peptides, compositions comprising them, chimeric molecules comprising them, and methods of using them to achieve transmembrane transport of various agents.
Claims14
A composition comprising a translocating peptide, wherein said translocating peptide is selected from the group consisting of a transport peptide, an extended peptide comprising said transport peptide, and a transport-active fragment of at least 4 contiguous amino acids of said transport peptide, wherein said transport peptide is selected from the group consisting of an L-peptide, a d-peptide, and a retroinverted peptide and wherein said L-peptide has an amino acid sequence selected from the group consisting of SEQ ID NOS:4-13 and 15-24, wherein said d-peptide has an amino acid sequence selected from the group consisting of SEQ ID NOS.60-82, and wherein the retroinverted peptide comprises a d-form amino acid sequence selected from the group consisting of a peptide of SEQ ID NOS.85-105.
A chimeric polypeptide comprising (A) a translocating peptide selected from the group consisting of a transport peptide, an extended peptide comprising said transport peptide, and a transport-active fragment of at least 4 contiguous amino acids of said transport peptide, wherein said transport peptide is selected from the group consisting of an L-peptide, a d-peptide, and a retroinverted peptide and wherein said L-peptide has an amino acid sequence selected from the group consisting of SEQ ID NOS:4-13 and 15-24, wherein said d-peptide has an amino acid sequence selected from the group consisting of SEQ ID NOS.60-82, and wherein the retroinverted peptide comprises a d-form amino acid sequence selected from the group consisting of a peptide of SEQ ID NOS.85-105, (B) a translocatable peptide, and (C) an amino acid linker sequence that directly links the tranlocating peptide to the translocatable peptide, wherein said translocatable peptide is between 3 and 200 amino acids, and wherein said amino acid linker sequence is between 1 and 20 amino acids.
A composition comprising a translocating peptide, said translocating peptide selected from the group consisting of a transport peptide and an extended peptide comprising said transport peptide, wherein said transport peptide is selected from the group consisting of an L-peptide, a d-peptide, and a retroinverted peptide and wherein said L-peptide has an amino acid sequence selected from the group consisting of SEQ ID NOS:4-13 and 15-24, wherein said d-peptide has an amino acid sequence selected from the group consisting of SEQ ID NOS.60-82, and wherein the retroinverted peptide comprises a d-form amino acid sequence selected from the group consisting of a peptide of SEQ ID NOS.85-105, and wherein said transport peptide is partially or completely cyclic.
A composition comprising a translocating peptide, said translocating peptide selected from the group consisting of a transport peptide, an extended peptide comprising said transport peptide, and a transport-active fragment of at least 9 contiguous amino acids of said transport peptide, wherein said transport peptide is selected from the group consisting of an L-peptide, a d-peptide, and a retroinverted peptide and wherein said L-peptide has an amino acid sequence selected from the group consisting of SEQ ID NOS:4-13 and 15-24, wherein said d-peptide has an amino acid sequence selected from the group consisting of SEQ ID NOS. 60-82, and wherein the retroinverted peptide comprises a d-form amino acid sequence selected from the group consisting of a peptide of SEQ ID NOS. 85-105, and wherein said transport peptide is partially or completely cyclic.
Dependencies are inferred from the claim text.