Novel synthetic n-linked sialo-glycan-containing polymer and method for producing the same

A production method of an N-linked sialo-glycan-containing polymer comprising:

• forming amide bond as a linker, a chemical compound having an amino group and a carboxyl group on each end of the compound respectively, with a 1-amino sugar in which a 1 position of a reducing terminal of the sugar is aminated and obtaining an N-linked asialo-glycan having an asialo-glycan part on a non-reducing terminal of a sugar;
• synthesizing an asialo-glycan-containing polymer by condensing the N-linked asialo-glycan to a carboxyl group of a polyglutamic acid via an amino group of the linker which is linked to a reducing terminal of the N-linked asialo-glycan;
• and
• obtaining the N-linked sialo-glycan-containing polymer by sialylation of the asialo-glycan-containing polymer.

A production method of an N-linked sialo-glycan-containing polymer comprising:

• forming amide bond as a linker, a chemical compound having an amino group and a carboxyl group on each end of the compound respectively, with a 1-amino sugar in which a 1 position of a reducing terminal of the sugar is aminated and obtaining an N-linked asialo-glycan having an asialo-glycan part on a non-reducing terminal of a sugar;
• obtaining the N-linked sialo-glycan in which a sialo-glycan is synthesized to the non-reducing terminal side by sialylation of the N-linked asialo-glycan;
• and
• synthesizing an sialo-glycan-containing polymer by condensing the N-linked sialo-glycan to a carboxyl group of a polyglutamic acid via an amino group of the linker which is linked to a reducing terminal of the N-linked sialo-glycan.