Bone cement and methods of use thereof
AssigneeDePuy Spine, Inc.
InventorsMordechay Beyar, Oren Globerman
Life of this patent
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Abstract
A bone cement comprising an acrylic polymer mixture which is formulated to have a relatively high viscosity for a relatively long window, due to distributions of molecular weights and/or sizes of acrylic beads.
Claims35
A bone cement comprising an acrylic polymer mixture, the cement characterized in that it achieves a viscosity of at least 500 Pascal-second within 180 seconds following initiation of mixing of a monomer component and a polymer component and characterized by sufficient biocompatibility to permit in-vivo use.
A bone cement comprising:
- a polymer component;
- and
- a monomer component;
- wherein contacting the polymer component and the monomer component produces a mixture which attains a viscosity greater than 200 Pascal-second within 1 minute from onset of mixing and remains below 2000 Pascal-second until at least 6 minutes from onset of mixing.
A particulate mixture formulated for preparation of a bone cement, the mixture comprising:
- (a) 60 to 80% polymer beads comprising a main sub-population characterized by an MW of 150,000 Dalton to 300,000 Dalton and a high molecular weight sub-population characterized by an MW of 3,000,000 Dalton to 4,000,000 Dalton;
- and
- (b) 20 to 40% of a material which is non-transparent with respect to X-ray.
A method of making a polymeric bone cement, the method comprising:
- (a) defining a viscosity profile including a rapid transition to a working window characterized by a high viscosity;
- (b) selecting a polymer component and a monomer component to produce a cement conforming to the viscosity profile;
- and
- (c) mixing the polymer component and a monomer component to produce a cement which conforms to the viscosity profile.
A cement kit, comprising:
- (a) a liquid component including a monomer;
- and
- (b) a powder component including polymeric beads,
- characterized in that said powder component is provided in a substantially non-normal distribution of at least one of molecular weight of the polymeric beads and size of powder particles such that a cement mixed from the kit has both an increased immediate viscosity and an increased working window as compared to a cement having a substantially normal distribution.
Dependencies are inferred from the claim text.