Use of cyclohexanehexol derivatives in the treatment of ocular disease

A medicament for treating an ocular disease comprising a therapeutically effective amount of a cyclohexanehexol compound of the formula III or IV:

• wherein X is a cyclohexane ring, wherein R1, R2, R3, R4, R5, and R6 are hydroxyl or at least one of R1, R2, R3, R4, R5, and R6 is independently selected from hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6alkoxy, C2-C6 alkenyloxy, C3-C10 cycloalkyl, C4-C10cycloalkenyl, C3-C10cycloalkoxy, C6-C10aryl, C6-C10aryloxy, C6-C10aryl-C1-C3alkoxy, C6-C10aroyl, C6-C10heteroaryl, C3-C10heterocyclic, C1-C6acyl, C1-C6acyloxy, —NH2, —NHR7, —NR7R8, ═NR7, —S(O)2R7, —SH, —SO3H, nitro, cyano, halo, haloalkyl, haloalkoxy, hydroxy alkyl, —Si(R7)3, —OSi(R7)3, —CO2H, —CO2R7, oxo, —PO3H, —NHC(O)R7, —C(O)NH2, —C(O)NHR7, —C(O)NR7R8, —NHS(O)2R7, —S(O)2NH2, —S(O)2NHR7, and —S(O)2NR7R8 wherein R7 and R8 are independently selected from C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C10cycloalkyl, C4-C10cycloalkenyl, C6-C10aryl, C6-C10 aryl C1-C3alkyl, C6-C10 heteroaryl and C3-C10heterocyclic, and at least one of the remainder of R1, R2, R3, R4, R5, or R6 is hydroxyl;
• or a pharmaceutically acceptable salt thereof.