Oligomer-Anticholinergic Agent Conjugates
AssigneeNektar Therapeutics
InventorsJennifer Riggs-Sauthier, Bo-Liang Deng
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Abstract
The invention provides anticholinergic agents that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different as compared to the characteristics of the anticholinergic agent not attached to the water-soluble oligomer.
Claims27
A compound comprising a residue of an anticholinergic agent covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer.
A composition comprising a compound comprising a residue of an anticholinergic agent covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer, and optionally, a pharmaceutically acceptable excipient.
A composition of matter comprising a compound comprising a residue of an anticholinergic agent covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer, wherein the compound is present in a dosage form.
A method comprising covalently attaching a water-soluble, non-peptidic oligomer to an anticholinergic agent.
A method comprising administering a compound comprising a residue of an anticholinergic agent covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer.
Dependencies are inferred from the claim text.