Target enzyme for the treatment of acne
AssigneeGalderma Research & Development
InventorsLaurent Lamy, Michel Rivier, Gérard Feraille
Life of this patent
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Abstract
The use of an enzyme as a research tool for acne, by identifying a compound for the treatment of acne and/or any disorder associated with cutaneous hyperseborrhoea.
Claims12
An in vitro method for screening and identifying candidate compounds for the preventative and/or curative treatment of a pathology selected from among acne, seborrhoeic dermatitis and cutaneous disorders associated with hyperseborrhoea, comprising determining the capacity of a compound to inhibit the expression or the activity of the human enzyme DHRS9 or the expression of its gene or the activity of at least one of its promoters.
A pharmaceutical composition comprising an inhibitor of the enzyme DHRS9 in an amount useful for the prevention and/or treatment of acne, seborrhoeic dermatitis or cutaneous disorders associated with hyperseborrhoea.
A cosmetic composition comprising an inhibitor of the human enzyme DHRS9, in an amount useful for the aesthetic treatment of oily skin.
An in vitro method for diagnosing or monitoring the evolution of acne, seborrhoeic dermatitis or a cutaneous disorder associated with hyperseborrhoea in a subject, comprising comparing the expression or the activity of the enzyme DHRS9, the expression of its gene or the activity of at least one of the promoters thereof, in a biological sample from a subject, with a biological sample from a control subject.
A kit for diagnosing acne, comprising the enzyme DHRS9.
An in vitro method for determining the susceptibility of a subject to developing acne, seborrhoeic dermatitis or a cutaneous disorder associated with hyperseborrhoea, comprising comparing the expression or the activity of the enzyme DHRS9, the expression of its gene or the activity of at least one of the promoters thereof, in a biological sample from a subject, with a biological sample from a control subject.
Dependencies are inferred from the claim text.