Small-Molecule Hepatitis C Virus (HCV) NS3/4A Serine Protease Inhibitors
OwnerFrancois Jean, Raymond Anderseninventors
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Abstract
Compounds of Formula 5 and prodrug compounds of Formula 5 wherein G1 is H or OH; G2 is H, R′, or CO2R′; G3, G4 and G5, are each independently selected from the group consisting of: H, R′, OH, OR′, F, Cl, Br, I, NH2, NHR′,NR′2, CN, SH, SR′, SO3H, SO3R′, SO2R′, OSO3R′, and NO2; and R′ is a one to four carbon alkyl group are provided. Uses of these compounds and methods of medical treatment involving these compounds for the treatment of hepatitis C are also provided.
Claims61
A prodrug compound of Formula 5:
- wherein
- G1 is H or OH;
- G2 is H, R′, or CO2R′;
- G3, G4 and G5, are each independently selected from the group consisting of:
- H, R′, OH, OR′, F, Cl, Br, I, NH2, NHR′, NR′2, CN, SH, SR′, SO3H, SO3R′, SO2R′, OSO3R′, and NO2;
- each R′ is independently a one to four carbon alkyl group;
- and
- from 1 to 5 OH moieties are replaced with a prodrug moiety.
Use of a compound of Formula 5:
- wherein
- G1 is H or OH;
- G2 is H, R′, or CO2R;
- G3, G4 and G5 are each independently selected from the group consisting of:
- H, R′, OH, OR′, F, Cl, Br, I, NH2, NHR′, NR′2, CN, SH, SR′, SO3H, SO3R′, SO2R′, OSO3R′, and NO2;
- and
- R′ is a one to four carbon alkyl group,
- for treatment of hepatitis C.
Use of a compound of Formula 5:
- wherein
- G1 is H or OH;
- G2 is H, R′, or CO2R;
- G3, G4 and G5 are each independently selected from the group consisting of:
- H, R′, OH, OR′, F, Cl, Br, I, NH2, NHR′, NR′2, CN, SH, SR′, SO3H, SO3R′, SO2R′, OSO3R′, and NO2;
- and
- R′ is a one to four carbon alkyl group,
- for preparation of a medicament for treatment of hepatitis C.
Use of a compound having the structure:
- for the treatment of hepatitis C.
Use of a compound having the structure:
- for the preparation of a medicament for the treatment of hepatitis C.
Use of a compound having the structure:
- for the treatment of hepatitis C.
Use of a compound having the structure:
- for the preparation of a medicament for the treatment of hepatitis C.
Use of a compound having the structure:
- for the treatment of hepatitis C.
Use of a compound having the structure:
- for the preparation of a medicament for the treatment of hepatitis C.
Use of a compound having the structure:
- for the treatment of hepatitis C.
Use of a compound having the structure:
- for the preparation of a medicament for the treatment of hepatitis C.
Use of a compound having the structure:
- for the treatment of hepatitis C.
Use of a compound having the structure:
- for the preparation of a medicament for the treatment of hepatitis C.
Use of a compound having the structure:
- for the treatment of hepatitis C.
Use of a compound having the structure:
- for the preparation of a medicament for the treatment of hepatitis C.
Use of a compound having the structure:
- for the treatment of hepatitis C.
Use of a compound having the structure:
- for the preparation of a medicament for the treatment of hepatitis C.
A method for treating hepatitis C comprising administering a therapeutically effective amount of a compound of Formula 5 or a prodrug compound of Formula 5:
- wherein
- G1 is H, or OH;
- G2 is H, R′, or CO2R′;
- G3, G4 and G5, are each independently selected from the group consisting of:
- H, R′, OH, OR′, F, Cl, Br, I, NH2, NHR′, NR′2, CN, SH, SR′, SO3H, SO3R′, SO2R′, OSO3R′, and NO2;
- R′ is a one to four carbon alkyl group;
- and
- from 0 to 5 OH moieties are replaced with a prodrug moiety,
- to a subject in need thereof.
The method of any one of claims 40 to 58 wherein the prodrug moiety is a 1 to 6 carbon alkyl-ester moiety.
The method of any one of claims 40 to 58 wherein the prodrug moiety is not a 1 to 6 carbon alkyl-ester moiety.
A method for treating hepatitis C comprising administering a therapeutically effective amount of a compound having the structure:
- to a subject in need thereof.
A method for treating hepatitis C comprising administering a therapeutically effective amount of a compound having the structure:
- to a subject in need thereof.
A method for treating hepatitis C comprising administering a therapeutically effective amount of a compound having the structure:
- to a subject in need thereof.
A method for treating hepatitis C comprising administering a therapeutically effective amount of a compound having the structure:
- to a subject in need thereof.
A method for treating hepatitis C comprising administering a therapeutically effective amount of a compound having the structure:
- to a subject in need thereof.
A method for treating hepatitis C comprising administering a therapeutically effective amount of a compound having the structure:
- to a subject in need thereof.
A method for treating hepatitis C comprising administering a therapeutically effective amount of a compound having the structure:
- to a subject in need thereof.
Dependencies are inferred from the claim text.