Methods and compositions for the treatment of neurological disease
AssigneeNeurologix, Inc.
InventorsMatthew J. During, Annamaria Vezzani
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Abstract
The present invention relates to a method for delivering a nucleic acid sequence encoding neuropeptide Y, or a derivative or functional fragment thereof, to a mammalian nervous system target cell. The expression of exogenous NPY, or a derivative or a functional fragment thereof in the target cell(s) provides therapeutic benefit for subjects afflicted with a neurological disorder.
Claims56
A method for delivering a nucleic acid sequence to a mammalian nervous system target cell, wherein said nucleic acid sequence is expressible in the target cell for greater than three months, said method comprising administering an expression vector to the target cell, wherein said expression vector comprises a nucleic acid sequence encoding neuropeptide Y, or a derivative or functional fragment thereof.
An AAV vector which retains only the replication and packaging signals of AAV, and which comprises a nucleic acid sequence encoding neuropeptide Y, or a derivative or a functional fragment thereof.
A method for treating a mammal with a neurological disease, said method comprising administering an expression vector to a target cell in the mammal, wherein said expression vector comprises a nucleic acid sequence encoding neuropeptide Y, or a derivative or functional fragment thereof, and wherein said administering results in expression of neuropeptide Y, or a derivative or functional fragment thereof, in said target cell and said expression reduces the symptoms of the neurological disease, thereby treating the mammal with the neurological disease.
Dependencies are inferred from the claim text.