Apoptosis inducer for cancer cell
AssigneeGenecare Research Institute Co., Ltd.
InventorsMotoki Takagi, Akira Shimamoto, Yasuhiro Furuichi, Ayumi Sato
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Abstract
The present invention revealed that by suppressing the expression of the WRN gene, the BLM gene, or the RecQ1 gene, which belong to the RecQ helicase family, apoptosis is induced in various cancer cells and their proliferation is suppressed. Compounds that suppress the expression of RecQ helicase family genes or the functions of RecQ helicase proteins are thought to have the activity of inducing apoptosis.
Claims5
A method for inducing apoptosis of cancer cells comprising a step of administering a compound that suppresses the expression of a gene belonging to the RecQ DNA helicase family into a subject, wherein the compound induces apoptosis in cancer cells but does not induce apoptosis in normal cells.
Dependencies are inferred from the claim text.