Therapeutic substituted lactams

A compound having a formula

• or a pharmaceutically acceptable salt thereof;
• Y is an organic acid functional group, or an amide or ester thereof comprising up to 14 carbon atoms;
• or Y is hydroxymethyl or an ether thereof comprising up to 14 carbon atoms;
• or Y is a tetrazolyl functional group;
• A is —(CH2)6—, cis —CH2CH═CH—(CH2)3—, or —CH2C≡C—(CH2)3—, wherein 1 or 2 carbon atoms may be replaced by S or O;
• or A is —(CH2)m—Ar—(CH2)o— wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein 1 —CH2— may be replaced by S or O, and 1 —CH2—CH2— may be replaced by —CH═CH— or —C≡C—;
• and
• B is substituted aryl or heteroaryl.