Fat regulation
AssigneeFibroGen, Inc.
InventorsPatrick D. Fourney, Volkmar Guenzler-Pukall, Stephen J. Klaus, Al Y. Lin, Thomas B. Neff, Todd W. Seeley
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Abstract
The present invention provides methods and compounds for regulating fat metabolism and achieving fat homeostasis in a subject. Methods and compound for regulating body weight, reducing body fat, and inducing weight loss are also provided, as are methods and compounds for treating or preventing obesity and for preventing or treating conditions associated with altered fat metabolism including, e.g., obesity, diabetes, atherosclerosis, etc.
Claims28
-33. (canceled)
A method for treating obesity in an obese subject, the method comprising administering to the subject an effective amount of a heterocyclic carboxamide compound which inhibits a hypoxia inducible factor (HIF) hydroxylase, thereby treating the obesity in the subject.
A method for regulating body weight in a subject in need thereof, the method comprising administering to the subject an effective amount of a heterocyclic carboxamide compound which inhibits a HIF hydroxylase, thereby regulating body weight in the subject.
A method for reducing body fat in a subject in need thereof, the method comprising administering to the subject an effective amount of a heterocyclic carboxamide compound which inhibits a HIF hydroxylase, thereby reducing body fat in the subject.
A method for reducing serum triglyceride levels in a subject in need thereof, the method comprising administering to the subject an effective amount of a heterocyclic carboxamide compound which inhibits a HIF hydroxylase, thereby reducing triglyceride levels in the subject.
Dependencies are inferred from the claim text.