Drugs with anticholestatic activity

A compound of formula (I)

• where
• R1 and R2 are chosen from —OH or —OCH3, otherwise R1 and R2 taken together form a —O—C(CH3)2—O— group,
• the ring A is chosen from:
• Y is chosen from H and —CO—CH3,
• X is chosen from CH2, O, S, NH, NR3, N—COR3,
• where R3 denotes:
• a) a linear or branched alkyl group having 1 to 9 carbon atoms,
• b) a (CH2)n—R4 chain, where n is 0 to 8 and R4 is chosen from OH, NH2, halogen, a cycloalkyl, aryl or heterocyclic group, with the proviso that when n is 1, R4 is not phenyl, or
• c) a (CH2)m—Z—(CH2)nCH3 chain, where m+n is 1 to 8, and Z denotes —O—, —S—, —NH—, —N(R5), where R5 is a linear or branched alkyl having 1 to 9 carbon atoms.

Method for the treatment of cholestasis and diseases related thereto comprising the administration of a compound of formula (I)

• where
• R1 and R2 are chosen from —OH or —OCH3, otherwise R1 and R2 taken together form a —O—C(CH3)2—O— group,
• the ring A is chosen from:
• Y is chosen from H and —CO—CH3,
• X is chosen from CH2, O, S, NH, NR3, N—COR3,
• where R3 denotes:
• a) a linear or branched alkyl group having 1 to 9 carbon atoms,
• b) a (CH2)n—R4 chain, where n is 0 to 8, and R4 is chosen from OH, NH2, halogen, a cycloalkyl, aryl or heterocyclic group,
• c) a (CH2)m—Z—(CH2)nCH3 chain, where m+n is 1 to 8, and Z denotes —O—, —S—, —NH—, —N(R5), where R5 is a linear or branched alkyl having 1 to 9 carbon atoms.