2-Substituted and 4-substituted aryl nitrone compounds

A compound of formula (11),

• or a pharmaceutically acceptable salt or solvate thereof, wherein:
• R1 is selected from H and lower alkyl;
• R2 is selected from lower alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heteroarylalkyl and cycloheteroalkyl;
• at least one of A and B is C—R3, and the other is selected from C—R3 and N;
• at least one R3 is SO2NR5R6, and the other R3 is independently selected from R4, H, lower alkyl, alkenyl, halogen, aryl, SO2NR5R6, SO2R5, CO2H, CONR5R6 and tetrazole;
• X, Y and Z are each independently selected from C—R4 and N;
• each R4 is independently selected from hydrogen, alkyl, substituted alkyl, acyl, substituted acyl, acylamino, substituted acylamino, alkylamino, substituted alkylamino, alkylthio, substituted alkylthio, alkoxy, substituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, alkylarylamino, substituted alkylarylamino, arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted arylalkyl, sulfoxide, sulfinyl, substituted sulfinyl, sulfonyl, substituted sulfonyl, sulfanyl, substituted sulfanyl, aminosulfonyl, substituted aminosulfonyl, arylsulfonyl, substituted arylsulfonyl, sulfo, substituted sulfo, dihydroxyphosphoryl, substituted dihydroxyphosphoryl, aminohydroxyphosphoryl, substituted aminohydroxyphosphoryl, azido, carbamoyl, substituted carbamoyl, carboxyl, cyano, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, dialkylamino, substituted dialkylamino, halo, heteroaryloxy, substituted heteroaryloxy, heteroaryl, substituted heteroaryl, heteroalkyl, substituted heteroalkyl, hydroxyl, nitro or thiol;
• and
• R5 and R6 are each independently selected from H, lower alkyl, aryl and heteroaryl, or join together to form a saturated or unsaturated cycloheteroalkyl ring containing 4 to 8 atoms, having zero, one or more heteroatoms selected from NR1, O and S.

A compound of formula (21),

• or a pharmaceutically acceptable salt or solvate thereof, wherein:
• R1 is selected from Hand lower alkyl;
• R2 is selected from lower alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heteroarylalkyl and cycloheteroalkyl;
• Y is C—R9, and R9 is selected from SO2NR5R6, SO2R5 and tetrazole;
• A, B, X and Z are each independently selected from C—R4 and N;
• each R4 is independently selected from hydrogen, alkyl, substituted alkyl, acyl, substituted acyl, acylamino, substituted acylamino, alkylamino, substituted alkylamino, alkylthio, substituted alkylthio, alkoxy, substituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, alkylarylamino, substituted alkylarylamino, arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted arylalkyl, sulfinyl, substituted sulfinyl, sulfonyl, sulfanyl, substituted sulfanyl, aminosulfonyl, substituted aminosulfonyl, arylsulfonyl, substituted arylsulfonyl, sulfo, substituted sulfo, dihydroxyphosphoryl, substituted dihydroxyphosphoryl, aminohydroxyphosphoryl, substituted aminohydroxyphosphoryl, azido, carbamoyl, substituted carbamoyl, carboxyl, cyano, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, dialkylamino, substituted dialkylamino, halo, heteroaryloxy, substituted heteroaryloxy, heteroaryl, substituted heteroaryl, heteroalkyl, substituted heteroalkyl, hydroxyl, nitro or thiol;
• and
• R5 and R6 are each independently selected from H, lower alkyl, alkyl, aryl and heteroaryl, or join together to form a saturated or unsaturated cycloheteroalkyl ring containing 4 to 8 atoms, having zero, one or more heteroatoms selected from NR1, O and S.