Back to results
US 2010/0168107 A1Published application
Imidazole compounds for the treatment of neurodegenerative disorders
AssigneePfizer Inc.
InventorsMichael A. Brodney, Karen J. Coffman
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
Claims23
1-22. (canceled)
A compound of Formula I,
- wherein:
- A is absent;
- R1 is benzo(C5-C6 cycloalkyl) optionally substituted with from one to three substituents independently selected from C1-C6 alkyl, halo, and —OH;
- R2 is hydrogen or C1-C6 alkyl;
- R3 is hydrogen or C1-C6 alkyl;
- R4 is hydrogen or C1-C6 alkyl;
- R6 is hydrogen or C1-C6 alkyl;
- R7 is C1-C10 alkyl, wherein R7 is optionally substituted with from one to three substituents independently selected from C1-C8 alkoxy, —OH, —NR9R10, —C(═O)NR9R10, —C(═O)R11, and —C(═O)OR11;
- and
- R9, R10, and R11 are each independently selected from hydrogen and C1-C6 alkyl, wherein each hydrogen atom of said C1-C6 alkyl is optionally independently replaced with a halo atom;
- or
- a pharmaceutically acceptable salt thereof.
9 more elements
A compound of Formula I,
- wherein:
- A is absent;
- R1 is benzo(C5-C6 cycloalkyl) optionally substituted with from one to three independently selected halo;
- R2 is hydrogen or C1-C6 alkyl;
- R3 is hydrogen, —CH2CH2SCH3, —O(C1-C4)alkyl or C1-C6 alkyl;
- R4 is hydrogen or C1-C6 alkyl;
- R6 is hydrogen or C1-C6 alkyl;
- R7 is C1-C10 alkyl, wherein R7 is optionally substituted with from one to three substituents independently selected from C1-C8 alkoxy, —OH, —NR9R10, —C(═O)NR9R10, —C(═O)R11, —C(═O)OR11, and (4-6 membered) heterocycloalkyl;
- and
- R9, R10, and R11 are each independently selected from hydrogen and C1-C6 alkyl, wherein each hydrogen atom of said C1-C6 alkyl is optionally independently replaced with a halo atom;
- or
- a pharmaceutically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.