Hiv inhibiting 5-amido substituted pyrimidines

A compound of formula

• or a stereochemically isomeric form thereof, or a pharmaceutically acceptable addition salt thereof, or a pharmaceutically acceptable hydrate or solvate thereof, or a N-oxide thereof, wherein
• each R1 independently is hydrogen;
• aryl;
• formyl;
• C1-6alkylcarbonyl;
• C1-6alkyl;
• C1-6alkyloxycarbonyl;
• R2, R3, R7 and R8 independently are hydrogen;
• hydroxy;
• halo;
• C3-7cycloalkyl;
• C1-6alkyloxy;
• carboxyl;
• C1-6alkyloxycarbonyl;
• cyano;
• nitro;
• amino;
• mono- or di(C1-6alkyl)amino;
• polyhaloC1-6alkyl;
• polyhaloC1-6alkyloxy;
• —C(═O)R10;
• C1-6alkyl optionally substituted with halo, cyano, or —C(═O)R10;
• C2-6alkenyl optionally substituted with halo, cyano or —C(═O)R10;
• C2-6alkynyl optionally substituted with halo, cyano, or —C(═O)R10;
• R4 and R9 independently are hydroxy;
• halo;
• C3-7cycloalkyl;
• C1-6alkyloxy;
• carboxyl;
• C1-6alkyloxycarbonyl;
• formyl;
• cyano;
• nitro;
• amino;
• mono- or di(C1-6alkyl)amino;
• polyhaloC1-6alkyl;
• polyhaloC1-6alkyloxy;
• —C(═O)R10;
• —S(═O)rR10;
• —NH—S(═O)rR10;
• —NHC(═O)H;
• —C(═O)NHNH2;
• —NHC(═O)R10;
• Het;
• -Y-Het;
• C1-12alkyl optionally substituted with halo, cyano, amino, mono- or di(C1-6alkyl)amino, —C(═O)—R10, Het or with C1-6alkyloxy;
• C2-12alkenyl optionally substituted with halo, cyano, amino, mono- or di(C1-6alkyl)amino, —C(═O)—R10, Het or with C1-6alkyloxy;
• C2-12alkynyl optionally substituted with halo, cyano, amino, mono- or di(C1-6alkyl)amino, —C(═O)—R10, Het, or with C1-6alkyloxy;
• R5 is C3-7cycloalkyl;
• C1-6alkyloxy;
• aryl;
• Het;
• C1-6alkyl substituted with a radical selected from hydroxy, C1-6alkyloxy, cyano, amino, mono- and di-C1-6alkylamino, C1-6alkylcarbonylamino, aryl, Het, dioxolanyl optionally substituted with one or two C1-6alkyl radicals, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, piperazinyl optionally substituted with C1-6alkyl or C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, arylC1-6alkyloxycarbonyl, and C3-7cycloalkyl;
• or R5 is C1-6alkyl substituted with two C1-6alkyloxy radicals;
• R6 is hydrogen or C1-6alkyl;
• or
• R5 and R6 taken together with the nitrogen atom to which they are attached form pyrrolidinyl;
• piperidinyl;
• morpholinyl;
• piperazinyl;
• piperazinyl optionally substituted with C1-6alkyl or C1-6alkylcarbonyl;
• each R10 independently is C1-6alkyl, amino, mono- or di(C1-6alkyl)amino, or
• polyhalo-C1-6alkyl;
• X is —NR1—, —O—, —C(═O)—, —CH2—, —CHOH—, —S—, —S(═O)r—;
• each Y independently is —NR1—, —O—, —C(═O)—, —S—, —S(═O)r—;
• each r independently is 1 or 2;
• each Het independently is pyridyl, thienyl, furanyl, oxazolyl, thiazolyl, thiadiazolyl, oxadiazolyl, isoxazolyl, isothiazolyl, imidazolyl, triazolyl, tetrazolyl, pyrazolyl, quinolinyl, benzothienyl, benzofuranyl, benzoxazolyl, benzothiazolyl;
• which each may optionally be substituted with one or two substituents each independently selected from C1-6alkyl, halo, hydroxy, cyano, C1-6alkyloxy, C2-12alkenyl substituted with halo, hydroxy or with cyano;
• each aryl independently is phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from halo, hydroxy, mercapto, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, hydroxyC1-6alkyl, aminoC1-6alkyl, mono and di(C1-6alkyl)-amino-C1-6alkyl, C1-6alkylcarbonyl, C3-7cycloalkyl, C1-6alkyloxy, phenylC1-6alkyloxy, C1-6alkyloxycarbonyl, aminosulfonyl, C1-6alkylthio, cyano, nitro, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, aminocarbonyl, phenyl, Het, and -Y-Het.