Utilization of tace inhibitors for the treatment of acne
AssigneeGalderma Research & Development
InventorsJÉRÔME AUBERT, ISABELLE CARLAVAN, JOHANNES VOEGEL
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Abstract
An in vitro method of screening for candidate compounds for the preventive or curative treatment of acne entails determination of the ability of a compound to inhibit the expression or the activity of TACE, and also to the administration of inhibitors of the expression or of the activity of this enzyme, in the treatment of acne.
Claims7
An in vitro method of screening for candidate compounds for the preventive and/or curative treatment of acne, comprising determining the ability of a compound to inhibit the expression or the activity of the TACE enzyme, or the expression of its gene or the activity of at least one of the promoters thereof, and thus identifying such candidate compound.
A regime or regimen for the preventive and/or curative treatment of acne, comprising administering to an individual in need of such treatment, a medicament which comprises a thus effective amount of at least one inhibitor of the TACE enzyme, said medicament being devoid of cyclooxygenase-2 inhibitor.
Dependencies are inferred from the claim text.