Superparamagnetic nanoparticle encapsulated with stimuli responsive polymer for drug delivery
OwnerDevesh Kumar Misrainventor
Life of this patent
Estimating the term…
Abstract
The current invention is a novel superparamagnetic site-targeting nanoparticle comprising superparamagnetic nanoparticles encapsulated with a smart polymer. The superparamagnetic site-targeting nanoparticle comprises a functionalized superparamagnetic core that is conjugated with a therapeutic agent and then encapsulated with a smart polymer. The smart polymer can be any polymer that exhibits a reversible conformational or physio-chemical change in response to an external stimulus or stimuli.
Claims20
A superparamagnetic nanoparticle comprising:
- (a) a core having responsivity to a magnetic field, wherein said core comprises a surface;
- (b) a therapeutic agent conjugated to said surface of said core;
- and
- (c) a stimuli-responsive polymer encapsulating said core and said therapeutic agent.
A method for making superparamagnetic nanoparticles, comprising the steps:
- (a) making a nanoparticle core having responsivity to a magnetic field, said nanoparticle comprising a surface;
- (b) functionalizing said surface of said nanoparticle core;
- (c) conjugating a therapeutic agent to said surface of said functionalized nanoparticle core;
- and
- (d) encapsulating said conjugated therapeutic agent and said nanoparticle core with a stimuli-responsive polymer.
A method for making a superparamagnetic nanoparticle encapsulated with a stimuli-responsive polymer, comprising the steps:
- (a) making a nanoparticle core having responsivity to a magnetic field, said nanoparticle comprising a surface;
- (b) functionalizing said surface of said nanoparticle core with a —NHNH2 functional group;
- (c) conjugating a therapeutic agent to said surface of said functionalized nanoparticle core;
- and
- (d) encapsulating said conjugated therapeutic agent and said functionalized nanoparticle core with a stimuli-responsive polymer.
Dependencies are inferred from the claim text.