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US 2010/0168028 A1Published application
Compositions and methods of using crmp-1 and its fragments for treating cancer
AssigneeAdvpharma Inc.
InventorsHARN-JING TERNG, YI-JEN LEE, WOAN-JEN LEE
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Abstract
Active fragments of hcrmp1 that are capable of inhibiting cell proliferation, invasive activity, and metastasis of cancer and methods of using the same for treating cancer are disclosed. The method can also be used prior to, or in combination with, the administration a chemotherapy agent. Vectors capable of expressing an hcrmp1, variants of hcrmp1, fragments of hcrmp1 and/or variants of fragments of hcrmp1 are also disclosed.
Claims20
An isolated polypeptide, which is a fragment of CRMP-1 protein that comprises the amino acid sequence of SEQ ID NO:
- 1, wherein the isolated polypeptide has no longer than 500 amino acid residues in length and is active in inhibiting the proliferation, metastasis, and/or invasion of a cancer cell.
Dependencies are inferred from the claim text.