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OwnerPeter Kiessling, Dietrich Bosse +2inventors
InventorsPeter Kiessling, Dietrich Bosse, Johannes Zeiss, Gaston Diderrich
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The invention relates to the improvement of the transport properties of albumin which is produced on an industrial scale, e.g. via the Cohn process or by means of recombinant processes, and is mixed, during the production process, with substances that saturate the binding points on the albumin and thus affect the binding properties and transport properties of the final product. A special embodiment of the invention relates to pasteurized and then octanoate-reduced human albumin for therapeutic use, especially in a detoxification treatment of human plasma, e.g. for the intravenous treatment of acute or chronic liver diseases, and as a dialysate in extracorporeal liver dialysis with albumin in the molecular adsorbent recirculating system (MARS) or in single-pass dialysis.
-12. (canceled)
An albumin preparation, wherein more than about 50% of substances bound to the albumin are removed during production of the albumin preparation, and wherein the binding capacity of the albumin preparation is improved compared to an albumin preparation in which said more than about 50% of substances are not removed during production.
An albumin preparation, wherein, during the production process, substances blocking binding sites of albumin are added and more than about 50% of said substances are subsequently removed, and wherein the binding capacity of the albumin preparation is improved compared to an albumin preparation in which said substances blocking binding sites are added but the more than about 50% of said substances are not subsequently removed.
Dependencies are inferred from the claim text.