Method for stimulation collagen synthesis and/or kgf expression

A method for treating skin aging, comprising administering to a subject in need thereof an effective amount of one selected from the group consisting of:

• (a) an isolated polypeptide having an amino acid sequence set forth in SEQ ID NO:
• 1;
• (b) an isolated polypeptide having an amino acid sequence homology of at least 70% with the polypeptide (a);
• and
• (c) a fragment of the polypeptide (a) or (b).

A method for treating the flaccid and/or wrinkled skin, comprising administering to a subject in need thereof an effective amount of one selected from the group consisting of:

• (a) an isolated polypeptide having the amino acid sequence set forth in SEQ ID NO:
• 1;
• (b) an isolated polypeptide having the amino acid sequence homology of at least 70% with the polypeptide (a);
• and
• (c) a fragment of the polypeptide (a) or (b).

A method for promoting the smoothing and/or firming of the skin, comprising administration to a subject in need thereof of an effective amount of one selected from the group consisting of:

• (a) an isolated polypeptide having the amino acid sequence set forth in SEQ ID NO:
• 1;
• (b) an isolated polypeptide having the amino acid sequence homology of at least 70% with the polypeptide (a);
• and
• (c) a fragment of the polypeptide (a) or (b).

A method for treating adverse cutaneous effects of menopause, comprising administration to a subject in need thereof of an effective amount of one selected from the group consisting of:

• (a) an isolated polypeptide having the amino acid sequence set forth in SEQ ID NO:
• 1;
• (b) an isolated polypeptide having the amino acid sequence homology of at least 70% with the polypeptide (a);
• and
• (c) a fragment of the polypeptide (a) or (b).

A method for treating adverse effects of menopause on the collagen, comprising administration to a subject in need thereof of an effective amount of one selected from the group consisting of:

• (a) an isolated polypeptide having the amino acid sequence set forth in SEQ ID NO:
• 1;
• (b) an isolated polypeptide having the amino acid sequence homology of at least 70% with the polypeptide (a);
• and
• (c) a fragment of the polypeptide (a) or (b).

A composition for stimulating collagen synthesis and/or KGF expression, the composition comprising as an active ingredient one selected from the group consisting of:

• (a) an isolated polypeptide having the amino acid sequence set forth in SEQ ID NO:
• 1;
• (b) an isolated polypeptide having the amino acid sequence homology of at least 70% with the polypeptide (a);
• and
• (c) a fragment of the polypeptide (a) or (b).

A cosmetic composition for preventing skin aging, the composition comprising as an active ingredient one selected from the group consisting of:

• (a) an isolated polypeptide having the amino acid sequence set forth in SEQ ID NO:
• 1;
• (b) an isolated polypeptide having the amino acid sequence homology of at least 70% with the polypeptide (a);
• and
• (c) a fragment of the polypeptide (a) or (b).

Use of any one selected from the group consisting of the following, for preparing a composition for stimulating collagen synthesis and/or KGF expression, the composition comprising the one as an active ingredient:

• (a) an isolated polypeptide having the amino acid sequence set forth in SEQ ID NO:1;
• (b) an isolated polypeptide having the amino acid sequence homology of at least 70% with the polypeptide (a);
• and
• (c) a fragment of the polypeptide (a) or (b).

Use of any one selected from the group consisting of the following proteins, for preparing a cosmetic composition for preventing skin aging, the composition comprising the one as an active ingredient:

• (a) an isolated polypeptide having the amino acid sequence set forth in SEQ ID NO:
• 1;
• (b) an isolated polypeptide having the amino acid sequence homology of at least 70% with the polypeptide (a);
• and
• (c) a fragment of the polypeptide (a) or (b).