3-Ether and 3-Thioether Substituted Cyclosporin Derivatives For the Treatment and Prevention of Hepatitis C Infection
OwnerHans Georg Fliri, David Renwick Houckinventors
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Abstract
This invention relates to cyclosporin derivatives of general formula (I): wherein A, B, R1, R2 and X are as defined in the specification, and pharmaceutical compositions prepared from the same, for use in treatment of hepatitis C virus.
Claims9
-20. (canceled)
A pharmaceutically acceptable salt of 3-[(R)-2-(N,N-dimethylamino)ethylthio-Sar]-4-(gamma-hydroxymethylleucine)cyclosporin.
A composition comprising a pharmaceutically acceptable salt of 3-[(R)-2-(N,N-dimethylamino)ethylthio-Sar]-4-(gamma-hydroxymethylleucine)cyclosporin, in combination with one or more compatible and pharmaceutically acceptable carriers.
A composition comprising a pharmaceutically acceptable salt of 3-[(R)-2-(N,N-dimethylamino)ethylthio-Sar]-4-(gamma-hydroxymethylleucine)cyclosporin, and one or more other anti-HCV agents.
Dependencies are inferred from the claim text.