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US 2010/0167994 A1Published application
Targeting of ews-fli1 as anti-tumor therapy
AssigneeGeorgetown University
InventorsJeffrey A. Toretsky, Aykut Üren, Milton Lang Brown, Yali Kong
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Abstract
Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
Claims12
A compound having a formula:
- or salt thereof.
A method for treating cancer comprising administering an effective amount of a compound having a formula:
- or pharmaceutically acceptable salt thereof to a subject in need thereof.
A pharmaceutical composition comprising a compound having a formula:
- or pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier or diluent.
Dependencies are inferred from the claim text.