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AssigneeCornell University
InventorsRajiv R. Ratan, Brett C. Langley, Brian S. Ko
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The present invention relates to a method for identifying a drug candidate for enhancing expression of p21ctpl/wafl in a human patient suffering from a medical condition that can be treated by enhancing expression of p21Cφl/wafl. The method includes (a) providing a cell line comprising a nucleic acid sequence that comprises a p21ctpl/wafl promoter operationally ligated to a reporter domain; (b) exposing the cell line to a compound; and (c) identifying a compound that induces expression of the reporter domain. The compound that induces expression of the reporter domain is a drug candidate for treating a medical condition that can be treated by enhancing expression of p21cipl/wafl.
A method for identifying a drug candidate for enhancing expression of p21cipl/wafl in a human patient suffering from a medical condition that can be treated by enhancing expression of p21cipl/wafl, the method comprising:
A method for enhancing expression of p21cipl/wafl in a human patient suffering from a medical condition that can be treated by enhancing expression of p21cipl/wafl, the method comprising administering to the patient an effective amount of a compound selected from the group consisting of ciclopirox olamine, dihydrocelastrol, colistimethate sodium, lycorine, diphenylurea, and acetylcysteine, chloroquine diphosphate, and 4′-methoxyflavone (acacetin).
Dependencies are inferred from the claim text.