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AssigneePower3 Medical Products, Inc.
InventorsIra L. Goldknopf, Jennifer K. Bryson, Essam A. Sheta, Jaffer K. Khalil, Silvia C. Quintero
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The present invention relates to identification and uses of biomarkers for neurodegenerative disease, including Alzheimer's disease, and the related diseases. More specifically, the present invention relates to the identification of protein biomarkers useful for the screening, diagnosis, and differentiation of Alzheimer's disease from Parkinson's disease, other neurodegenerative diseases, and normal controls, and in the monitoring of Alzheimer's disease severity and disease mechanisms in patients.
A Method of use of protein biomarkers of neurodegenerative disease comprising two or more biomarkers in a biological sample, wherein the detection and/or the concentration of a first biomarker is employed to sort between categories of neurodegenerative disease patients and categories of normal and disease controls, and the presence and/or concentration of the first biomarker and of one or more additional biomarkers are then employed within each category for screening, diagnosis, differential diagnosis and monitoring of neurodegenerative disease severity and of disease mechanisms in the patients.
The method of 1 wherein the biological sample is Cerebrospinal Fluid, urine, or tissue.
Dependencies are inferred from the claim text.