US 2010/0167420 A1Published application

Micro Mechanical Methods and Systems for Performing Assays

AssigneeMec Dynamics Corporation

InventorEmmanuel C. Mpock

Life of this patent

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Abstract

The present invention provides a micro mechanical system for performing assays for determining the presence of one or more selected analytes in a sample. The device comprises of a base and a disposable strip with at least one reaction well and at least one moveable member capable of moving fluids and parts through the fluids in a defined reaction well. Reagents in the reaction chambers and or the moveable members, react with the sample to yield a physically detectable change. The moveable parts are capable of executing motions that either mix, move reaction components, exchange or systematically deliver reagents to targets in the cartridge. Sensors in the base are configured to detect and or quantify the presence of a sample in the reaction well and of analytes in the sample. The signal is converted to an output on a visual display window on the external part of the base.

Claims10

Dependent claims

A method for determining the percentage of hemoglobin that is HbA1c, the method comprising:

providing a disposable strip comprising a first solid substrate comprising a sample well, a reference well, and a reaction well, wherein the wells are in fluidic communication via a first capillary channel, and wherein the reference well comprises a first lysing agent and the reaction well comprises a second lysing agent, a HbA1c specific antibody, and a stir bar;
a second solid substrate comprising holes wherein the first solid substrate and the second solid substrate are joined and the holes communicate with the wells;
and a membrane having a capture zone wherein the membrane is connected to the reaction well via a second capillary channel;
placing a sample in the sample application well;
adding a diluent to the sample application well;
determining the total hemoglobin from the reference cell and the total HbA1c from the capture zone;
and
dividing the total HbA1c by total hemoglobin to obtain the percentage of hemoglobin that is HbA1c.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application: 12/722,469Filed 11 Mar 2010
Priority: 29 Oct 2003
Published: 1 Jul 2010
Term ends: Not estimatedThe source records don’t support an estimate.

Classification4 codes

G01N 33/54386
Apparatus specially adapted for solid-phase testing: analytical elements
G01N 33/54366
With an insoluble carrier for immobilising immunochemicals: apparatus specially adapted for solid-phase testing
G01N 33/721
Involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood: haemoglobin
G01N
Investigating or analysing materials by determining their chemical or physical properties

Family

Application60/515,731Us provisional application · filed 29 Oct 2003
Application10/976,651Division · filed 29 Oct 2004
Application12/722,469Division
US 2005/0136551 A1Published application
US 7,939,030 B2Related patent
US 7,988,932 B2Related patent
US 2010/0167420 A1This patent

From the US filing history. Foreign family members aren’t listed.

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