Back to results
US 2010/0167399 A1Published application
Method of generating regulatory t cells using cord blood and adult blood cd14+ monocyte cells
AssigneeLoyola University of Chicago
InventorMakio Iwashima
Life of this patent
Estimating the term…
Abstract
A method of inducing stable and functional Tregs from human umbilical cord blood and adult blood without requiring the expansion of pre-existing Tregs. The method utilizes CD14+ monocyte cells present in or isolated from cord blood or adult blood to induce functional Tregs from T cells, and particularly T cells that express CD4+, which may also be obtained from cord blood or adult blood. The developed Tregs are long-lasting and maintain their suppressive functions.
Claims20
A method of inducing functional regulatory T cells by stimulating T cells with CD14+ monocyte cells obtained from cord blood or adult blood.
Dependencies are inferred from the claim text.