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AssigneesBayer HealthCare LLC, The Johns Hopkins University
InventorsJohn Edward Murphy, Konstantin Borislavov Konstantinov, John Christopher Thrift, Tarangsri Nivitchanyong, Michael Betenbaugh
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The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell expressing recombinant Factor VIII such that programmed cell death in the cell is prevented or delayed. The present invention also relates to increasing production of recombinant Factor VIII by expressing one or more anti-apoptotic polypeptides in a cell such that production of recombinant Factor VIII by the cell is increased. Recombinant cells useful for producing Factor VIII.
A method for preventing or delaying programmed cell death in a cell expressing recombinant Factor VIII comprising expressing one or more anti-apoptotic polypeptides in the cell such that programmed cell death in the cell is prevented or delayed.
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A method of increasing production of Factor VIII by a recombinant cell comprising expressing one or more anti-apoptotic polypeptides in the cell such that production of Factor VIII by the cell is increased.
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A recombinant cell useful for producing Factor VIII expressing or capable of expressing at least two anti-apoptotic polypeptides.
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Dependencies are inferred from the claim text.