Back to results
US 2010/0167393 A1Published application
Modified human thymic stromal lymphopoietin
AssigneeImmunex Corporation
InventorsStewart D. LYMAN, Kirk P. VAN NESS, Raymond J. PAXTON
Life of this patent
Estimating the term…
Abstract
Modified, furin resistant human TSLP polypeptides and polynucleotides encoding the modified human TSLP polypeptides are provided. Pharmaceutical compositions, B and T cell activation agents, assays and methods of use are also described.
Claims21
An isolated nucleic acid molecule comprising a polynucleotide encoding a polypeptide having at least 90% amino acid sequence identity to SEQ ID NO:
- 4, wherein the polypeptide comprises a modification to inactivate the furin cleavage site RRKRK at position 127-131 of SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.