Preparation of virally inactivated biological fluids having high alpha-2-antiplasmin activity
AssigneeResearch Foundation for Medical Devices
InventorsThierry Burnouf, Magdy El-Ekiaby, Hadi Alphonse Goubran, Miryana Radosevich
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Abstract
The invention relates to the use of polyoxyethylene (4-5) p-t-octyl phenol (t-Oct-C6H4—(OCH2CH2)x0H, x=˜5) or polyoxyethylene (20) sorbitan monooleate in solvent/detergent viral inactivation of biological fluids for the preparation of a virally inactivated biological fluid having a high alpha 2-antiplasmin content.
Claims14
1-8. (canceled)
Method of solvent/detergent virally inactivating a biological fluid comprising adding polyoxyethylene (4-5) p-t-octyl phenol (t-Oct-C6H4—(OCH2CH2)xOH, x=˜5) or polyoxyethylene (20) sorbitan monooleate to said biological fluid, wherein the virally inactivated biological fluid has an alpha-2-antiplasmin (α2-AP) activity of at least 85% of the initial alpha-2-antiplasmin activity.
Dependencies are inferred from the claim text.