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AssigneeDsm IP Assets B.V.
InventorsAlbertus Alard Van Dijk, Natalja Alekseevna Cyplenkova, Petrus Jacobus Theodorus Dekker, Yulia M. Efimova
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The present invention relates to an isolated polypeptide which has sialidase activity, selected from the group consisting of: (a) a polypeptide which has an amino acid sequence which has at least 60% amino acid sequence identity with amino acids 1 to 407 of SEQ ID NO: 3; (b) a polypeptide which is encoded by a polynucleotide which hybridizes under low stringency conditions with (i) the nucleic acid sequence of SEQ ID NO: 1 or 2 which is at least 80% or 90% identical over 60, preferably over 100 nucleotides, more preferably at least 90% identical over 200 nucleotides, or (ii) a nucleic acid sequence complementary to the nucleic acid sequence of SEQ ID NO: 1 or 2.
An isolated polypeptide which has sialidase activity and which has an amino acid sequence which has at least 60% amino acid sequence identity with amino acids 1 to 407 of SEQ ID NO:
A fungal polypeptide which has a MW (molecular weight) of less than 55 kDa (SDS-Page), more preferably the polypeptide has a MW (molecular weight) of less than 52 kDa (SDS-Page) or the polypeptide has a MW (molecular weight) of less than 50 kDa (calculated on basis of amino acid sequence), more preferably the polypeptide has a MW (molecular weight) of less than 45 kDa (calculated on basis of amino acid sequence).
A polypeptide having sialidase activity and which is non-virulent or a polypeptide having sialidase activity, which is a fungal sialidase and which has a MW (molecular weight) of less than 55 kDa (SDS-page), more preferably the sialidase has a MW (molecular weight) of less than 52 kDa (SDS-page) or the sialidase has a MW (molecular weight) of less than 50 kDa (calculated on basis of amino acid sequence), more preferably the sialidase has a MW (molecular weight) of less than 45 kDa (calculated on basis of amino acid sequence).
Dependencies are inferred from the claim text.