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US 2010/0167335 A1Published application
Methods for diagnosing and treating allergies
AssigneeThe Research Foundation of State University of New York
InventorsRauno Joks, Stephan Kohlhoff
Life of this patent
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Abstract
The present invention relates to methods of screening actives for the treatment of allergic reactions and providing treatment therefor. In particular, the invention relates to the screening of various antibacterial actives for treatment of asthma and other related symptoms.
Claims26
A method of screening actives for treatment in a mammal comprising the steps of:
- a. Providing a sample of mammalian peripheral blood mononuclear cells;
- b. Exposing said mammalian peripheral blood mononuclear cells to an agent to stimulate an allergic response in said mammalian peripheral blood mononuclear cells;
- c. Treating said stimulated mammalian peripheral blood mononuclear cells with at least one active;
- and
- d. Observing the response of said stimulated mammalian peripheral blood mononuclear cells after treatment with said active.
2 more elements
A method of screening assays for a disorder comprising:
- a. Providing a sample of mammalian peripheral blood mononuclear cells;
- b. Exposing said mammalian peripheral blood mononuclear cells to an agent to stimulate an allergic response in said mammalian peripheral blood mononuclear cells;
- c. Treating said stimulated mammalian peripheral blood mononuclear cells with at least one active;
- and
- d. Observing the response of said stimulated mammalian peripheral blood mononuclear cells after treatment with said active.
2 more elements
A method of treating a patient comprising the steps of:
- a. Screening an active for use in treating said patient comprising the steps of:
- i. Extracting from said patient a sample of peripheral blood mononuclear cells;
- ii. Exposing said mammalian peripheral blood mononuclear cells to an agent to stimulate an allergic response in said mammalian peripheral blood mononuclear cells;
- iii. Treating said stimulated mammalian peripheral blood mononuclear cells with at least one active;
- and
- iv. Observing the treated response of said stimulated mammalian peripheral blood mononuclear cells after treatment with said active;
- b. Selecting an active which provides a desired treated response;
- and
- c. Administering a dosage of said active to said patient.
6 more elements
Dependencies are inferred from the claim text.