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US 2010/0167329 A1Published application
Device for drug screening
AssigneeRespiratorius AB
InventorMats Wokander
Life of this patent
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Abstract
The present invention discloses a device and an optical liquid sensor for drug screening, and a method for using these. More particularly a device, an optical liquid sensor, and a method, for repeatable measurements of the effect of a test drug on a biological tissue sample are described.
Claims17
A device for measuring the effect of a drug on at least one tissue sample, comprising:
- a chamber defining a volume, said chamber further comprising an inlet and outlet to said chamber, whereby a perfusion liquid, comprising said drug, may enter and leave said chamber, wherein said perfusion liquid transporting said drug to said biological tissue sample in said chamber,
- an optical liquid level sensor for controlling the liquid level in said chamber, mounting means for mounting said at least one tissue sample to force transducers, and
- measuring means for measuring a contraction or relaxation of said at least one tissue sample by a signal from said force transducers.
An optical liquid level sensor unit for measuring a distance to a surface to be measured, which optical liquid sensor unit comprises:
- an optical liquid level sensor, comprising
- a light source,
- a light transmitting optical fiber for transmitting light from said light source to the surface to be measured,
- a light receiving optical fiber for receiving light reflected from the surface to be measured in a chamber, and
- a reflected light sensor for transducing a reflected light into a reflection signal;
- and
- control means for receiving a signal from said optical liquid level sensor and operating a valve controlling the flow from the chamber.
4 more elements
A method for measuring the effect of a drug on at least one tissue sample, comprising:
- perfusing said at least one tissue sample with a perfusion liquid in a chamber defining a volume, said chamber further comprising an inlet and outlet to said chamber, whereby said perfusion liquid, comprising said drug, may enter and leave said chamber, wherein said perfusion liquid transporting said drug to said biological tissue sample in said chamber,
- controlling the liquid level in said chamber with an optical liquid level sensor,
- mounting said at least one tissue sample to force transducers, and
- measuring a contraction or relaxation of said at least one tissue sample by a signal from said force transducers.
1 more element
Dependencies are inferred from the claim text.