Control of intracellular target molecule by ip3 receptor-binding protein
AssigneeJapan Science and Technology Agency
InventorsKatsuhiko Mikoshiba, Hideaki Ando, Akihiro Mizutani
Life of this patent
Estimating the term…
Abstract
The present invention provides a composition comprising an IP3 receptor-binding protein (IRBIT), a nucleic acid that controls the expression and translation of IRBIT, or an antibody against IRBIT for controlling at least one intracellular biological function selected from the group consisting of (1) protein synthesis, (2) phosphatidylinositol metabolism, and (3) intracellular pH.
Claims20
A composition comprising an IP3 receptor-binding protein (IRBIT), a nucleic acid which controls the expression and translation of IRBIT, or an antibody against IRBIT, wherein the composition is for controlling at least one intracellular biological function selected from the group consisting of:
- (1) protein synthesis;
- (2) phosphatidylinositol metabolism;
- and
- (3) intracellular pH.
Use of IRBIT in in vitro or ex vivo control of the synthesis of proteins within cells.
Use of IRBIT in in vitro or ex vivo control of the metabolism of phosphatidylinositol within cells.
Use of IRBIT in in vitro or ex vivo control of a pH within cells.
A method for screening for a substance, comprising measuring a binding of IRBIT to CPSF, PIPKII, or pNBC1 in the presence of a candidate substance and then identifying a substance that suppresses or elevates said binding.
Dependencies are inferred from the claim text.