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US 2010/0167271 A1Published application
Method for screening blood using a preservative that may be in a substantially solid state form
AssigneeStreck, Inc.
InventorWayne L. Ryan
Life of this patent
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Abstract
Methods and devices useful for screening a blood product for a transfusion, pursuant to which leukocytes in drawn whole blood are contacted with a formaldehyde releaser screening preservative so that the presence of any residual leukocytes can be screened. A substantially solid state form preservative for one or more blood components (e.g., leukocytes) and use thereof is also described.
Claims20
A method for screening a blood product for a transfusion, comprising the steps of:
- contacting a leuko-reduced drawn blood sample with a screening preservative composition that is (i) in a substantially solid state form;
- and (ii) includes a formaldehyde releaser agent selected from the group consisting of diazolidinyl urea, imidazolidinyl urea, dimethoylol-5,5-dimethylhydantoin, dimethylol urea, 2-bromo-2.-nitropropane-1,3-diol, an oxazolidine, sodium hydroxymethyl glycinate, hydroxymethoxymethyl-1-1aza-3,7-dioxabicyclo [3.3.0]octane, 5-hydroxymethyl-1-1-aza-3,7dioxabicyclo [3.3.0]octane, 5-hydroxypoly[methyleneoxy]methyl-1-1aza-3,7dioxabicyclo [3.3.0]octane, quaternary adamantine and any combination thereof;
- and
- optionally, screening any residual leukocytes prior to a blood transfusion.
1 more element
A device comprising:
- a) a receptacle that receives a sample of blood and that is substantially transparent over at least a portion of its area;
- b) a screening preservative composition contacting the receptacle and being visible through the substantially transparent window, the screening preservative composition having a viscosity so that it remains substantially fixed in a single location prior to receiving the sample of blood, but which is of sufficient concentration so that upon contact with the sample of blood the screening preservative composition will disperse in the sample, and substantially preserve white blood cell components in the sample.
A device for screening blood comprising:
- a. a first end;
- b. an intermediate location where the cross section about the longitudinal axis of the device changes from constant to variable;
- c. a second end;
- d. a non-planar base that extends between the second end and toward or away from the intermediate location;
- e. a sectional volume per unit length between the second end and the intermediate location that is less than that between the first end and the intermediate location;
- wherein a preservative composition is supported between the first end and second end.
3 more elements
Dependencies are inferred from the claim text.