US 2010/0167260 A1 · Use of N-Piperidine Derivative Compositions for Protecting Biological Systems

Abstract

The present invention relates to compositions and the use of such compositions in the formulation of preservation solutions for protecting mammalian (including human) biological systems such as biotechnological preparations (including recombin 10d3 ant proteins), organs, tissues (including whole blood and blood derivatives such platelets and plasma) and cells (including red blood cells, pancreatic ss-cells, stem cells and germ cells) from oxidative damage occurring, for example, during the different phases of transplantation and surgery. More particularly, this invention relates to a method for protecting and/or enhancing viability of mammalian biotechnological preparations/cells/tissues/organs during isolation (or harvesting), preservation (or storage), expansion (or colture), transplantation and surgery by using compositions containing effective amount of antioxidant cyclic (bis)-hydroxylamines derived from N-piperidine. Data supplied from the esp@cenet database—Worldwide

Claims16

Dependent claims

A method for preserving and/or enhancing the viability ex vivo of a mammalian biological system, comprising contacting said biological system with a preservation solution comprising a compound of formula:

in which:
R1, R2, R3 and R4 are, independently of one another, hydrogen or alkyl having from 1 to 6 carbon atoms, R6 is oxyl or hydroxyl, and R5 is
in which R1, R2, R3 and R4 are, independently of one another, hydrogen or alkyl having from 1 to 6 carbon atoms, R7 is oxyl or hydroxyl, and n is a whole number from 2 to 14;
or a physiologically acceptable salt of said compound.

1 more element

Dependencies are inferred from the claim text.

Use of N-Piperidine Derivative Compositions for Protecting Biological Systems

Life of this patent

Use of N-Piperidine Derivative Compositions for Protecting Biological Systems

Life of this patent

Abstract

Claims16