DIBENZO[b,e][1,4]DIAZEPINE MODULATORS OF DOPAMINE RECEPTORS, SEROTONIN RECEPTORS, ADRENERGIC RECEPTORS, ACETYLCHOLINE RECEPTORS, AND/OR HISTAMINE RECEPTORS

A pharmaceutical composition comprising a pharmaceutically acceptable carrier together with a compound of structural Formula I

• or a salt thereof, wherein:
• R1-R19 are independently selected from the group consisting of hydrogen and deuterium;
• and
• at least one of R1-R19 is deuterium.

A method of treatment of a dopamine receptor-mediated disorder, a serotonin receptor-mediated disorder, an adrenergic receptor-mediated disorder, an acetylcholine receptor-mediated disorder, or a histamine receptor-mediated disorder comprising the administration, to a patient in need thereof, of a therapeutically effective amount of a compound of structural Formula I

• or a salt thereof, wherein:
• R1-R19 are independently selected from the group consisting of hydrogen and deuterium;
• and
• at least one of R1-R19 is deuterium.

A compound for use as a medicament, said compound having structural Formula I

• or a salt thereof, wherein:
• R1-R19 are independently selected from the group consisting of hydrogen and deuterium;
• and
• at least one of R1-R19 is deuterium.

A compound for use in the manufacture of a medicament for the prevention or treatment of a disorder ameliorated by the modulation of dopamine receptors, serotonin receptors, adrenergic receptors, acetylcholine receptors, or histamine receptors, said compound having structural Formula I

• or a salt thereof, wherein:
• R1-R19 are independently selected from the group consisting of hydrogen and deuterium;
• and
• at least one of R1-R19 is deuterium.