Potentiation of cancer chemotherapy by 7-(2, 5- dihydro- 4-imidazo [1, 2-a] pyridine-3-yl-2,5-dioxo-ih-pyrrol-3-yl)-9-fluoro-1,2,3,4 tetrahydro -2-(1-piperidinyl-carbonyl)-pyrrolo [3,2,1-jk] [1,4] benzodiazepine

An improved method of using CPT-11, pemetrexed, gemcitabine, etoposide, doxorubicin, or a platinum chemotherapeutic agent in the treatment of ovarian cancer, non-small cell lung cancer, or colorectal cancer in a patient in need of such treatment, where the improvement comprises the co-administration of 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo[3,2,1-jk][1,4]benzodiazepine or a pharmaceutically acceptable salt or a solvate thereof.

5-7. (canceled)

A method of treating gastric cancer comprising administering to a cancer patient in need of such treatment an effective amount of a chemotherapeutic agent selected from the group consisting of 5-fluorouracil and platinum chemotherapeutic agents in combination with an effective amount of 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)-pyrrolo[3,2,1-jk][1,4]benzodiazepine or a pharmaceutically acceptable salt or a solvate thereof.

An improved method of using 5-fluorouracil or a platinum chemotherapeutic agent in the treatment of gastric cancer in a patient in need of such treatment, where the improvement comprises the co-administration of 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo[3,2,1-jk][1,4]benzodiazepine or a pharmaceutically acceptable salt or a solvate thereof.

(canceled)

A pharmaceutical composition capable of reconstitution with water to a solution suitable for administration to a patient by injection or infusion, comprising one molar equivalent of 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)-pyrrolo[3,2,1-jk][1,4]benzodiazepine or a pharmaceutically acceptable salt or solvate thereof, at least one molar equivalent of SBE7-β-CD, and optionally a pharmaceutically acceptable buffer.

A pharmaceutical composition comprising one molar equivalent of 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)-pyrrolo[3,2,1-jk][1,4]benzo-diazepine and at least one molar equivalent of SBE7-β-CD.

A method of treating ovarian cancer, non-small cell lung cancer, or colorectal cancer comprising administering to a cancer patient in need of such treatment an effective amount of pemetrexed and a platinum chemotherapeutic agent in combination with an effective amount of 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)-pyrrolo[3,2,1-jk][1,4]benzodiazepine or a pharmaceutically acceptable salt or a solvate thereof.

A method of treating gastric cancer comprising administering to a cancer patient in need of such treatment an effective amount of pemetrexed and a platinum chemotherapeutic agent in combination with an effective amount of 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)-pyrrolo[3,2,1-jk][1,4]benzodiazepine or a pharmaceutically acceptable salt or a solvate thereof.