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OwnerAmarjit Singh, Singh Sarabjit +2inventors
InventorsAmarjit Singh, Singh Sarabjit, Ajay K. Gupta, Mangesh M. Kulkarni
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The present invention relates to novel and improved compositions of anticancer drugs, preferably taxanes, such as paclitaxel and docetaxel, their derivatives or their analogues, methods of manufacturing these compositions and methods of fractionating the particles in particular size range and methods of treating cancer patients with these compositions, which provide reduced chemotherapy-induced side-effects especially reduced chemotherapy-induced-alopecia. The composition is such that there is substantially no free drug in the said composition.
Novel and improved compositions for cancer therapy having substantially reduced chemotherapy-induced side-effects like alopecia.
A method of treating a mammal for cancer therapy comprising the step of administering to the mammal a therapeutically effective amount of the said novel and improved compositions comprising particles of at least one anticancer drug and at least one polymer wherein the particles have D10≧80 nm, D50 of about 200 nm and D90≦450 nm and the composition being such that it has substantially no free drug and provides a substantially reduced chemotherapy-induced side-effects like alopecia.
A method for reducing chemotherapy-induced side-effects like alopecia of a cancer therapy in a mammal undergoing treatment with anticancer drugs, said method comprising administering a therapeutically effective amount of the said novel and improved compositions comprising particles of at least one anticancer drug and at least one polymer wherein the particles have D10≧80 nm, D50 of about 200 nm and D90≦450 nm and the composition being such that it has substantially no free drug.
Dependencies are inferred from the claim text.