Local Complement Inhibition for Treatment of Complement-Mediated Disorders
AssigneePotentia Pharmaceuticals, Inc.
InventorsCedric Francois, Pascal Deschatelets, Paul Olson
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Abstract
The present invention features the local administration of complement inhibitors for treatment of complement-mediated disorders. In certain embodiments the invention features inhibiting activation of one or more locally produced complement proteins. The invention provides sustained release formulations and devices comprising a complement inhibitor and methods of use thereof.
Claims80
A method of treating a complement-mediated disorder comprising the step of:
- administering a complement inhibitor directly to an extravascular location that is a site of local complement activation in said disorder.
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A composition comprising a complement inhibitor, wherein said composition comprises a gel, cream, lotion, or ointment suitable for application to the skin.
An inhalable composition comprising a complement inhibitor.
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A method of treating inflammatory arthritis comprising administering a complement inhibitor directly to a joint or bursa, wherein said complement inhibitor is administered in an amount effective to substantially inhibit activation of a locally produced soluble complement component.
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A method of treating an inflammatory condition of the respiratory system comprising administering a complement inhibitor directly to the respiratory tract, wherein said complement inhibitor is a peptide or antibody that binds to a locally produced soluble complement protein.
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A method of treating a complement-mediated disorder of the nervous system comprising administering a complement inhibitor to a region of the nervous system by a route selected from the group consisting of:
- intrathecal, intranasal, and by local injection into a nerve sheath.
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A method of treating a skin condition comprising administering a complement inhibitor directly to the skin, wherein said complement inhibitor is administered in an amount effective to inhibit activation of a locally produced soluble complement component or in an amount effective to inhibit local activation of complement and is not sufficient to significantly inhibit systemic complement activation when administered directly to the skin.
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A method of treating a complement-mediated disorder comprising administering a sustained release formulation comprising an effective amount of a compstatin analog to an extravascular location where complement activation occurs, wherein said location is not the eye.
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Dependencies are inferred from the claim text.