US 2010/0166856 A1 · PHARMACEUTICAL COMPOSITION IN THE FORM OF COATED MICROSPHERES FOR THE MODIFIED RELEASE OF A MUSCLE RELAXANT AND AN NSAID

Abstract

The invention relates to a modified release pharmaceutical composition in capsules with coated microspheres, combining two active ingredients with radically different plasma concentration times, namely a muscle relaxant (tizanidine) and a non-steroidal anti-inflammatory drug (meloxicam), and pharmaceutically acceptable excipients or vehicles; as well as a method for producing the composition and the use of said combination for the preparation of a drug having synergic therapeutic effect in the treatment of spasticity, disorders related to the skeletal muscle and/or muscular ailments, and moderate to severe pain in general.

Claims25

Dependent claims

A pharmaceutical composition characterized by the coated microspheres comprising:

a) inert cores coated with a first film formed by a muscle relaxant, at least one adhesive polymer, and at least one plasticizer;
b) a second delaying polymer film, at least one plasticizer, and a regulating solution;
and
c) a third film formed by a NSAID, the muscle relaxant of the first film, at least one adhesive polymer, at least one plasticizer, and at least one surfactant;
wherein the muscle relaxant shows a modified release, and the NSAID shows immediate release.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

12/446,293Filed 16 Oct 2007

Priority

MX PA/A/2006/01202418 Oct 2006

Published

1 Jul 2010

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61K 31/5415
Having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame: ortho- or peri-condensed with…
A61K 9/2081
Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets: with microcapsules or…
A61K 9/5078
Having two or more different coatings optionally including drug-containing subcoatings: with drug-free core
A61K 31/433
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: thidiazoles

Pharmaceutical composition in the form of coated microspheres for the modified release of a muscle relaxant and an nsaid

Life of this patent

Pharmaceutical composition in the form of coated microspheres for the modified release of a muscle relaxant and an nsaid

Life of this patent

Abstract

Claims25