Liposomal formulations for treating cancer
OwnerJoseph Ciccolini, Raphaelle Fanciullinoinventors
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Abstract
The invention provides a pharmaceutical composition comprising liposomes which coencapsulate 5-fluorouracil (5-FU) and 2′-deoxyinosine (d-Ino). In a preferred embodiment, the liposomes comprise phosphatidylcholine (PC), phosphatidyl-glycol (PG) and sterol, preferably in a molar ratio PC/PG/sterol of 20-80/10-60/15-60. The invention further provides a method for preparing liposomes which coencapsulate 5-fluorouracil (5-FU) and 2′-deoxyinosine (d-Ino), and the use thereof for the manufacture of a medicament for treating cancer in a patient.
Claims20
A pharmaceutical composition comprising liposomes which coencapsulate 5-fluorouracil (5-FU) and 2′-deoxyinosine (d-Ino).
A method for preparing liposomes which coencapsulate 5-fluorouracil (5-FU) and 2′-deoxyinosine (d-Ino), which method comprises the steps consisting of
- (a) dissolving a lipid mixture comprising phosphatidylcholine (PC), phosphatidylglycol (PG) and sterol in an alcoholic solvent, and removing the solvent to form a lipid film;
- (b) hydrating the lipid film with a solution containing 5-fluorouracil and 2′-deoxyinosine, to form a lipid dispersion;
- (c) forming Multilamellar vesicles (MLVs) by mixing the lipid dispersion;
- (d) obtaining Small unilamellar vesicles (SUVs) therefrom, by sonication.
A method for treating cancer in a patient, which method comprises administering an effective amount of a pharmaceutical composition comprising liposomes which coencapsulate 5-fluorouracil (5-FU) and 2′-deoxyinosine (d-Ino) in a patient in need thereof.
Dependencies are inferred from the claim text.