Methods And Compositions For Modulating Keratinocyte Function
OwnerWendy Bollinger Bollag, Xiaofeng Zhong +1inventors
InventorsWendy Bollinger Bollag, Xiaofeng Zhong, Xiangjian Zheng
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Abstract
The disclosure is generally directed to methods and compositions for modulating keratinocyte function, more particularly, to compositions and methods for normalizing keratinocyte proliferation and differentiation, compositions and methods for modulating levels of phosphatidylglycerol (PG) in keratinocyes, and compositions and methods for treating skin conditions by modulating keratinocyte proliferation.
Claims25
A method for modulating keratinocyte function comprising:
- contacting a keratinocyte with an amount of phosphatidylglycerol, a functional derivative thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof, effective to modulate signal transduction in the keratinocyte.
A composition for treating a skin condition comprising an amount of phosphatidylglycerol, a functional derivative thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof, effective to modulate skin cell signal transduction.
A composition for treating a skin condition comprising an amount of liposomes of phosphatidylglycerol, a functional derivative thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof, effective to modulate skin cell signal transduction.
A method of treating a skin condition comprising administering to a host an amount of phosphatidylglycerol, a functional derivative thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof, in an amount effective to treat the skin condition.
A method of treating a skin condition in a host comprising modulating the amount of phosphatidylglycerol, or a functional derivative thereof, in host keratinocytes.
23-37. (canceled)
A method of treating a skin condition in a host comprising, administering to the host an amount of phosphatidylglycerol, a functional derivative thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof, effective to treat the skin condition, wherein the phosphatidylglycerol stimulates skin cell proliferation when the skin condition is characterized by under-proliferation of skin cells, and wherein the phosphatidylglycerol inhibits skin cell proliferation when the skin condition is characterized by over-proliferation of skin cells.
39-40. (canceled)
Dependencies are inferred from the claim text.