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US 2010/0166829 A1Published application
Active agent eluting matrices with particulates
AssigneeSurModics, Inc.
InventorsJoram Slager, Aron B. Anderson
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Abstract
The present invention is directed to polymeric matrices for the controlled release of a hydrophilic bioactive agent. Generally, the elution control matrix includes a polymeric matrix having a first polymer and a plurality of microparticles that include the hydrophilic bioactive agent. In one embodiment, the matrix includes a polymer comprising hydrophilic and hydrophobic portions. In another embodiment, the microparticles include a crosslinked hydrophilic polymer.
Claims20
An elution control matrix for the controlled release of a hydrophilic bioactive agent, comprising a polymeric matrix comprising:
- a first polymer that is hydrophobic, wherein a portion or all of the polymeric matrix is formed from the first polymer;
- and
- a plurality of microparticles dispersed within the polymeric matrix;
- wherein the microparticles comprise a hydrophilic bioactive agent and crosslinked hydrophilic polymer.
1 more element
Dependencies are inferred from the claim text.