Periostin induces proliferation of cardiomyocytes and promotes cardiac regeneration
AssigneeChildren's Medical Center Corporation
InventorBernhard Kuhn
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Abstract
The present invention provides compositions and methods for increasing proliferation, increasing cell cycle activity, and/or proliferation of postmitotic mammalian differentiated cardiomyocytes. The invention can be used to slow, reduce, or prevent the onset of cardiac damage caused by, for example, myocardial ischemia, hypoxia, stroke, or myocardial infarction in vivo. In addition, the methods and compositions of the invention can be used to enhance proliferation of differentiated cardiomyocytes in vitro and/or ex vivo, which can then be used in tissue grafting.
Claims34
-4. (canceled)
A method of inducing division of post mitotic cells, the method comprising administering an integrin activator to a subject in an amount effective to stimulate division of the post-mitotic cells.
A pharmaceutical composition to treat damaged heart tissue comprising an effective amount of an integrin activator and a pharmaceutically acceptable carrier, diluent or medium, to induce proliferation of post-mitotic cardiomyocytes.
Dependencies are inferred from the claim text.